Definition of diethylnitrosamine-induced rat hepatic precancerous lesions with atypia index
نویسندگان
چکیده
منابع مشابه
Hepatic precancerous lesions and small hepatocellular carcinoma.
Precancerous lesions that may be detected in chronically diseased, usually cirrhotic livers, include: clusters of hepatocytes with atypia and increased proliferative rate (dysplastic foci) that usually represent an incidental finding in biopsy or resection specimens; and grossly evident lesions (dysplastic nodules) that may be detected on radiologic examination. There are two types of small hep...
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BACKGROUND Nonalcoholic fatty liver disease (NAFLD) is a risk for hepatocellular carcinoma (HCC), but the association between a high-fructose diet and HCC is not fully understood. In this study, we investigated whether a high-fructose diet affects hepatocarcinogenesis induced by administration of diethylnitrosamine (DEN). METHODS Seven-week-old male Sprague-Dawley rats were fed standard chow ...
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The effects of streptozotocin (STZ)-induced diabetes on induction of hepatic preneoplastic lesions by diethylnitrosamine (DEN) were investigated in male Fischer rats. A single dose of STZ was injected intravenously either 2 weeks before or after initiation with DEN. The blood glucose levels were significantly elevated from 1 week after STZ-injection until autopsy. The numbers of GST-P positive ...
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Background: Precancerous lesions are disorders that are highlylikely to become malignant. Early diagnosis of precancerous skinlesions helps to prevent skin cancers. The aim of this study wasclinicopathological assessment of precancerous skin lesions inpatients referred to the dermatology department of Imam Rezahospital.Method: Two hundred and nine patients who were diagnosed withprecancerous le...
متن کاملChemoprevention by lipid-soluble tea polyphenols in diethylnitrosamine/phenobarbital-induced hepatic pre-cancerous lesions.
BACKGROUND Green tea polyphenols (GTPs) have been proposed as promising candidates for chemoprevention. However, GTPs levels are maintained relatively low in the blood and are chemically-unstable. Lipid-soluble tea polyphenols (LTPs) are products of modified GTPs with ester linkage with fatty acids. LTPs are lipophilic and expected to provide improved absorption and utilization in the body comp...
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ژورنال
عنوان ژورنال: World Chinese Journal of Digestology
سال: 2012
ISSN: 2219-2859
DOI: 10.11569/wcjd.v20.i27.2562